37  IGHV4-39/IGHV4-38-2

37.1 Allele appearnce

The group of IGHV4-39(IGHVF8-G45) includes 11 functional alleles within it.

For each allele we counted the number of appearances across the population, any appearance was considered valid.

37.2 Group alignment

Based on the viewd alleles, we calculated the distance between the germline sequences.

37.3 Sequence depth

To examine the potential cutoff we observed the sequence depth for each allele

37.4 Absolute cutoff

We set an initial cutoff of \(0.01\%\) to determine the potential genotype priors. For this cutoff we examined the zygousity state, such as homozygousity, heterozygousity and so on.

37.4.1 Allele specific cutoff

Observing the alleles frequencies we adapted the following thresholds

The graph below shows the allele-based individual genotype inference for this allele group.